G_func_fam: Simulate SNP for all subjects and liabilities for family

In Holdols/genstats: Analyse genetic data

Simulate SNP for all subjects and liabilities for family

Description

The function creates a bigsnpr object, saves it in a rds file and fills the file backed matrix generated with genotypes for each subject. The function also returns the genetic liabilities for the parents of the subject since the parents genotypes are not saved. The liabilities for the parents is therefore calculated in the same loop as the genotypes is simulated.

Usage

G_func_fam(
  filename,
  beta,
  MAF,
  N = 1e+05,
  M = 1e+05,
  n_sib = 0,
  block_size = 1000
)

Arguments

filename	Filename for file backed matrix(FBM) and rds file.
beta	A vector containing the casual effect of each SNP.
MAF	A vector containing minor allele frequencies.
N	Amount of subjects.
M	Amount of SNPs.
block_size	Size of FBM to be processed in each iteration.
n_sibs	Amount of siblings.

Value

List containing simulated SNPs for all subjects in a FBM and family's liabilities in a tibble.

Holdols/genstats documentation built on June 10, 2022, 6:05 a.m.