liabilities_func_fam: Calculate genetic liabilities and simulate enviromental...

In Holdols/genstats: Analyse genetic data

Calculate genetic liabilities and simulate enviromental liabilities for subject and family

Description

Helper function for gen_sim()

Usage

liabilities_func_fam(
  G,
  beta,
  MAF,
  liab,
  N = 1e+05,
  n_sib = 0,
  K = 0.05,
  h2 = 0.5,
  block_size = 1000
)

Arguments

G	File backed matrix containing SNP data.
beta	A vector containing the casual effect of each SNP.
MAF	A vector containing minor allele frequencies.
liab	A tibble containing genetic liabilities for each subject's family members.
N	Amount of subjects.
n_sib	Amount of siblings.
block_size	Size of FBM to be processed in each iteration.
h_2	The heritability of trait.

Value

A tibble containing genetic and full liability for each family member.

Holdols/genstats documentation built on June 10, 2022, 6:05 a.m.