R/translink_tdr.R

In HopkinsIDD/phylosamp: Sample Size Calculations for Molecular and Phylogenetic Studies

##' Calculate true discovery rate of identifying transmission pairs
##'
##' This function calculates the true discovery rate (proportion of true transmission pairs) in a sample given the sensitivity
##' and specificity of the linkage criteria, and sample size \eqn{M}. Assumptions about transmission and linkage (single or multiple)
##' can be specified.
##'
##' @param sensitivity scalar or vector giving the sensitivity of the linkage criteria
##' @param specificity scalar or vector giving the specificity of the linkage criteria
##' @param rho scalar or vector giving the proportion of the final outbreak size that is sampled
##' @param M scalar or vector giving the number of cases sampled
##' @param R scalar or vector giving the effective reproductive number of the pathogen (default=NULL)
##' @param assumption a character vector indicating which assumptions about transmission and linkage criteria. Default = `'mtml'`. Accepted arguments are:
##' \enumerate{
##'      \item `'stsl'` for the single-transmission single-linkage assumption.
##'      \item `'mtsl'` for the multiple-transmission single-linkage assumption.
##'      \item `'mtml'` for the multiple-transmission multiple-linkage assumption.
##'      }
##'
##' @return scalar or vector giving the true discovery rate
##'
##' @author John Giles, Shirlee Wohl, and Justin Lessler
##'
##' @examples
##' # The simplest case: single-transmission, single-linkage, and perfect sensitivity
##' translink_tdr(sensitivity=1, specificity=0.9, rho=0.5, M=100, assumption='stsl')
##'
##' # Multiple-transmission and imperfect sensitivity
##' translink_tdr(sensitivity=0.99, specificity=0.9, rho=1, M=50, R=1, assumption='mtsl')
##'
##' # Small outbreak, larger sampling proportion
##' translink_tdr(sensitivity=0.99, specificity=0.95, rho=1, M=50, R=1, assumption='mtml')
##'
##' # Large outbreak, small sampling proportion
##' translink_tdr(sensitivity=0.99, specificity=0.95, rho=0.5, M=1000, R=1, assumption='mtml')
##'
##' @family transmission linkage functions
##'
##' @export
##'

translink_tdr <- function(sensitivity, specificity, rho, M, R = NULL, assumption = "mtml") {
    if (assumption == "stsl") {
        message("Calculating true discovery rate assuming single-transmission and single-linkage")
        out <- translink_prob_transmit_stsl(sensitivity = sensitivity, specificity = specificity,
            rho = rho, M = M)
    } else if (assumption == "mtsl") {
        message("Calculating true discovery rate assuming multiple-transmission and single-linkage")
        out <- translink_prob_transmit_mtsl(sensitivity = sensitivity, specificity = specificity,
            rho = rho, M = M, R = R)
    } else if (assumption == "mtml") {
        message("Calculating true discovery rate assuming multiple-transmission and multiple-linkage")
        out <- translink_prob_transmit_mtml(sensitivity = sensitivity, specificity = specificity,
            rho = rho, M = M, R = R)
    } else {
        stop("Incorrect assumption argument")
    }

    return(out)
}