allsinglearm: Onestage combination function for optimal designs

In IDDI-BE/PhIIdesign: Sample Size Calculation for Phase II Designs

Description

This function calculates sample sizes of the Fleming 1-stage , Simon-2stage, Sargent's 1- and 2-stage design. calculations are performed jointly for different sets of proportions (p0, pA) and operating characteristics. All designs are summarized in 2 tables, 1 for one-stage designs (Fleming and sargent) and 1 for two-stage designs (Simon and sargent)

Usage

allsinglearm(p0, pa, alpha, beta, alpha2 = alpha, beta2, pi, eta, eps = 0.005)

Arguments

p0	uninteresting response (null hypothesis H0), can be a vector
pa	interesting response (alternative hypothesis Ha), can be a vector, always same length as p0. The corresponding elements of p0 and pa are taken as a set of proportions
alpha	P(reject H0|H0) for Fleming and Simon designs, can be a vector
beta	P(reject Ha|Ha) for Fleming and Simon designs, can be a vector
alpha2	P(reject H0|H0) for Sargent designs, can be a vector, same length as alpha
beta2	P(reject Ha|Ha) for Sargent designs, can be a vector, same length as beta
pi	P(reject H0|Ha) for Sargent designs, can be a vector, same length as beta2
eta	P(reject Ha|H0) for Sargent designs, can be a vector, same length as alpha2
eps	tolerance (actual alpha<=alpha+eps; actual beta<=beta+eps; actual eta>=eta-eps; actual p>=pi-eps); default value = 0.005

Examples

allsinglearm(p0 = 0.1, pa = 0.7,
             alpha = 0.05, alpha2 = 0.05, beta = 0.2, beta2 = 0.1, pi = 0.8, eta = 0.8)

IDDI-BE/PhIIdesign documentation built on June 5, 2021, 2:03 p.m.