simon2stage_prob_reject_Ha: P(reject Ha) in a 2-stage PhII single arm Simon design

In IDDI-BE/PhIIdesign: Sample Size Calculation for Phase II Designs

Description

This function calculates the P(reject alternative hypothesis|true success probability)

Usage

simon2stage_prob_reject_Ha(n1, n2, r1, r, p)

Arguments

n1	total number of patients in stage1
n2	total number of patients in stage2
r1	critical value for the first stage
r	critical value for the second stage
p	true success probability

Details

if x1<=r1 –> stop futility
if (x1+x2)<=r –> futility
with x1 the number of successes in the first stage and x2 the number of successes in the second stage

Value

Probability

References

Simon R. Optimal two-Stage Designs for Phase II Clinical Trials.
Control Clin Trials. 1989;10:1-10

Examples

simon2stage_prob_reject_Ha(n1=10,n2=20,r1=0,r=4,p=0.25)

IDDI-BE/PhIIdesign documentation built on June 5, 2021, 2:03 p.m.