calc_auc_analytic: Convenience function to calculate the AUC based on PK model...

In InsightRX/PKPDsim: Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations

Convenience function to calculate the AUC based on PK model parameters at any given moment, for linear iv models.

Description

Convenience function to calculate the AUC based on PK model parameters at any given moment, for linear iv models.

Usage

calc_auc_analytic(
  f = c("1cmt_iv_infusion", "2cmt_iv_infusion", "3cmt_iv_infusion", "1cmt_iv_bolus",
    "2cmt_iv_bolus", "3cmt_iv_bolus"),
  parameters,
  regimen = NULL,
  dose = NULL,
  interval = NULL,
  t_inf = NULL,
  t_obs = c(0, 24, 48, 72),
  ...
)

Arguments

f	analytic model to use, show available models using 'advan()'
parameters	list of parameter estimates. Requires CL/V for 1-compartment models, CL/V/Q/V2 for 2-compartment models, and CL/V/Q/V2/Q2/V3 for 3-compartment models.
regimen	PKPDsim regimen created using 'new_regimen'. Not required, regimen can also be specified using 'dose', 'interval', and 't_inf'.
dose	dosing amount for regimen (single value). Only used if no 'regimen' supplied.
interval	dosing interval for regimen (single value). Only used if no . 'regimen' supplied.
t_inf	infusion length for regimen (single value). Only used if no 'regimen' supplied.
t_obs	vector of observation times for AUC
...	optional arguments passed to 'advanc_create_data()'

Value

a data.frame with 't' and 'auc'

Examples

dat <- calc_auc_analytic(
  f = "2cmt_iv_infusion",
  regimen = new_regimen(
    amt = 1000, n = 10, type = "infusion",
    t_inf = 1, interval = 24
  ),
  parameters = list(CL = 5, V = 50, Q = 8, V2 = 150)
)

InsightRX/PKPDsim documentation built on April 25, 2024, 2:10 a.m.