calc_aki_stage: Calculate AKI stage

In InsightRX/clinPK: Clinical Pharmacokinetics Toolkit

Calculate AKI stage

Description

Calculate AKI class based on serum creatinine values over time, using various methods for children (pRIFLE) and adults (RIFLE, kDIGO)

Usage

calc_aki_stage(
  scr = NULL,
  times = NULL,
  method = "kdigo",
  baseline_scr = "median",
  baseline_egfr = NULL,
  first_dose_time = NULL,
  age = NULL,
  egfr = NULL,
  egfr_method = NULL,
  force_numeric = FALSE,
  override_prifle_baseline = FALSE,
  verbose = TRUE,
  return_object = TRUE,
  ...
)

Arguments

scr	serum creatinine in mg/dL. Use convert_creat() to convert from mmol/L. Values below the detection limit ("<0.2") will be converted to numeric (0.2)
times	creatinine sample times in hours
method	classification method, one of KDIGO, RIFLE, pRIFLE (case insensitive)
baseline_scr	baseline serum creatinine, required for RIFLE classifation. Will use value if numeric. If character, can be either median, median_before_treatment, lowest, or first.
baseline_egfr	baseline eGFR, required for RIFLE classifations. Will take median of egfr values if NULL.
first_dose_time	time in hours of first dose relative to sCr value, used for calculate baseline serum creatinine in median_before_treatment approach.
age	age in years, needed when eGFR is used in the classification method
egfr	eGFR in ml/min/1.73m^2. Optional, can also be calcualted if age, weight, height, sex, egfr_method are specified as arguments.
egfr_method	eGFR calculation method, used by calc_egfr(). If NULL, will pick default based on classification system (cockroft_gault for RIFLE / kDIGO, revised_schwartz for pRIFLE).
force_numeric	keep stage numeric (1, 2, or 3), instead of e.g. "R", "I", "F" as in RIFLE. Default FALSE.
override_prifle_baseline	by default, pRIFLE compares eGFR to 120 ml/min. Override by setting to TRUE.
verbose	verbose (TRUE or FALSE)
return_object	return object with detailed data (default TRUE). If FALSE, will just return maximum stage.
...	arguments passed on to calc_egfr()

References

• pRIFLE: Ackan-Arikan et al. "Modified RIFLE criteria in critically ill children with acute kidney injury." Kidney Int. (2007)

• RIFLE: Bellomo et al. "Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group." Critical Care. (2004)

• KDIGO: Khwaja. "KDIGO clinical practice guidelines for acute kidney injury." Nephron Clinical Practice. (2012)

• pRIFLE baseline eGFR: Soler et al. "pRIFLE (Pediatric Risk, Injury, Failure, Loss, End Stage Renal Disease) score identifies Acute Kidney Injury and predicts mortality in critically ill children : a prospective study." Pediatric Critical Care Medicine. (2014)

Examples

calc_aki_stage(
  scr = c(0.7, 0.9, 1.8, 1.5),
  t = c(0, 40, 100, 130),
  age = 50, weight = 60,
  height = 170, sex = "female")

InsightRX/clinPK documentation built on June 14, 2025, 9:48 p.m.