calc_creat: Estimate serum creatinine

In InsightRX/clinPK: Clinical Pharmacokinetics Toolkit

Estimate serum creatinine

Description

Calculate an estimated serum creatinine. Function takes vectorized input as well.

Usage

calc_creat(
  sex = NULL,
  age = NULL,
  weight = NULL,
  height = NULL,
  adult_method = c("johanssen", "brooks"),
  digits = 1
)

Arguments

sex	sex, either 'male' or 'female'
age	age in years
weight	weight in kg (default 75 kg)
height	height in cm (default 165 cm)
adult_method	estimation adult method, 'johanssen' (default) or 'brooks',
digits	number of digits to round to

Details

For children and adolescents: Uses equations described in Ceriotti et al. Clin Chem. 2008, and Junge W et al. Clin Chim Acta. 2004. For age 15-18, a linear interpolation is used between equations for <15 Johanssen A et al. Ther Drug Monit 2011. For adults: Two methods are available Johanssen et al. Ther Drug Monit 2011. which describes a flat serum creatinine dependent on sex, and Brooks et al (unpublished) which is a linear regression built on the NHANES open-source data and takes into account sex, age, weight, and height. Equation: 'lm(SCr~Age+Sex+Weight+Height, data=NHANES)'

Examples

calc_creat(sex = "male", age = 40)
calc_creat(sex = "male", age = 40, weight = 100, height = 175, adult_method = "brooks")
calc_creat(sex = "male", age = c(10, 17, 60))

InsightRX/clinPK documentation built on Jan. 18, 2025, 7:45 a.m.