calc_carboplatin_calvert: Calvert equation for carboplatin

In InsightRX/clinPK: Clinical Pharmacokinetics Toolkit

Calvert equation for carboplatin

Description

The Calvert equation calculates a dose expected to bring the patient to the target AUC given their glomerular filtration rate (GFR). The original equation was developed on a data set of 18 individuals with GFR of 33-136 ml/min.

Usage

calc_carboplatin_calvert(target_auc, gfr = NULL, ...)

Arguments

target_auc	target AUC, in mg/ml-min, typically between 2-8 mg/ml-min
gfr	glomerular filtration rate, in ml/min. See also clinPK::calc_egfr.
...	arguments passed on to calc_egfr if gfr is not supplied

References

Calvert et al., Journal of Clinical Oncology (1976)

Examples

calc_carboplatin_calvert(5, 100)
calc_carboplatin_calvert(4, 30)
calc_carboplatin_calvert(2, sex = "male", age = 50, scr = 1.1, weight = 70)

InsightRX/clinPK documentation built on June 14, 2025, 9:48 p.m.