ADNI: ADNI Data.

In LaiJiang/CIVMR: Constrained Instrumental Variables in Mendelian Randomization with Pleiotropy

Description

A dataset collected from ADNI project for MR analysis in the CIV paper. It contains 491 subjects, whose phenotypes (A β, Ptau, Ttau, Glucose levels) and Alzheimer's status were collected. 20 SNPs associated with A β were selected and their dosage of the 491 subjects were recorded. This data file is extracted to serve as an example to estimate the causal effect of A β on progression of Alzheimer's disease while accounting for potential pleiotropic effect from other phenotypes.

Usage

data(ADNI)

Arguments

ADNI$Y:	the Alzheimer's disease status. Continuous variable. The raw status is binary variable, and we adjusted it for confounding factors such as sex, age, education ... etc.
ADNI$X:	The phenotype of interest A β Continuous variable.
ADNI$Z:	The potential pleiotropic phenotypes (Ptau, Ttau, Glucose levels). Continuous variables.
ADNI$G:	genotypes. The adjusted dosage of 20 SNPs.

Format

An object of class "data.frame".

Examples

data(ADNI)
X <- ADNI$X
Z <- ADNI$Z
G <- ADNI$G
Y <- ADNI$Y

LaiJiang/CIVMR documentation built on July 16, 2020, 12:45 a.m.