simulation: simulation Data.

In LaiJiang/CIVMR: Constrained Instrumental Variables in Mendelian Randomization with Pleiotropy

Description

A simulated data using the same framework from simulation series I in the CIV paper. It contains 500 subjects with one phenotype (X) of interest, one pleiotropic phenotype (Z) and one outcome (Y) simulated for each subject. 9 SNPs were generated and they were associated with both X and Z. The true causal effect of X on Y is 1. This data file is simulated to serve as an example to estimate the causal effect of X on Y while accounting for potential pleiotropic effect from Z. Users can compare the performance of different MR methods on this simulation dataset since the true causal effect is known.

Usage

data(simulation)

Arguments

simulation$Y:	the simulated outcome Y. Continuous variable.
simulation$X:	The simulated phenotype of interest X. Continuous variable.
simulation$Z:	The potential pleiotropic phenotype Z. Continuous variable.
simulation$G:	The simulated genotypes. The dosage of 9 independent SNP variants were simulated with a minor allele frequency of 0.3 for all 500 subjects.

Format

An object of class "data.frame".

Examples

data(simulation)
X <- simulation$X
Z <- simulation$Z
geno <- simulation$G
outcome <- simulation$Y

LaiJiang/CIVMR documentation built on July 16, 2020, 12:45 a.m.