pcc_IV: multiple orthogonal CIV solutions. (internal function)

In LaiJiang/CIVMR: Constrained Instrumental Variables in Mendelian Randomization with Pleiotropy

Description

This function find multiple CIV solutions that are orthogonal to each other. Only the first one achive the global maximum correlation.

Usage

pcc_IV(A, B, G, inv_GG_square, no_IV = ncol(G) - ncol(B))

Arguments

A:	matrix given by LA_decomposition().
B:	matrix given by LA_decomposition().
G:	original instruments.

Value

u_max: the solution of u that would maximize the constrained correlation problem.

Examples

data(simulation)
#CIV linear algebra decomposition components
civ.deco <- LA_decomposition(simulation$G,simulation$X,simulation$Z)
#solve the CIV solution for c
civ.mult <- pcc_IV(civ.deco$A, civ.deco$B, simulation$G, civ.deco$inv_GG_square)

LaiJiang/CIVMR documentation built on July 16, 2020, 12:45 a.m.