eff: Efficacy response generation parameters

In LuZhangstat/Phase1Mayo: Personalized Repeated Measurement Design for Phase I Clinical Trials

Description

A list of 4 records the parameters for efficacy measure generation. This serves as an example of the parameter settings for efficacy measure generation in function SimPRMD. Check eff_summary or SimPRMD to see the examples of using dataset eff in generating efficacy measure.

Usage

eff

Format

An object of class list of length 4.

Value

Dose_Cycle_Meff	Dose-cycle mean efficacy matrix. An array of 4 dimension providing the mean of the multivariate Gaussian distribution in efficacy data generation. The dimension of the Dose-cycle mean efficacy matrix is 5 5 6 6 which represents dose efficacy pattern, cycle efficacy pattern, dose and cycle. Patterns are ordered in a way that the first is increasing, the second is flat, the third is platform, the fourth is decreasing, and the fifth is quadratic efficacy across dose levels and cycles.
Sigma	A 6 by 6 matrix, the covariance matrix of the multivariate Guassian distribution in efficacy data generation.
sd_trans	A positive number controls the skewness of the distribution of the efficacy response
eff.M	An array recording the corresponding mean of the generated efficacy data with parameters specified by eff$Dose_Cycle_Meff, eff$Sigma, and eff$sd_trans

LuZhangstat/Phase1Mayo documentation built on March 16, 2020, 1:32 a.m.