nTTP_summary: Generate the mean nTTP score and the probability of observing...

In LuZhangstat/Phase1Mayo: Personalized Repeated Measurement Design for Phase I Clinical Trials

Description

nTTP_summary generates the mean nTTP score and the probability of observing DLT for all doses and cycles

Usage

nTTP_summary(Tox.prob.M, nTTP.all, wm)

Arguments

Tox.prob.M	Toxicity probability matrix with 4 dimension: dose, cycle, type, grade. Tox.prob.M can be the output of the build-in matrix of function GenToxProb in package phase1RMD. See more details about how to generate toxicity probability matrices in the help document of GenToxProb.
nTTP.all	The output of nTTP.array
wm	(numerical matrix) Toxicity weighted matrix, with row be the type of the toxicity and column be the toxicity grade

Value

mnTTP.M	matrix of mean nTTP for all doses and cycles
pDLT.M	matrix of probability of observing DLT for all doses and cycles

Examples

data("prob")

wm <- matrix(c(0, 0.5, 0.75, 1, 1.5,
               0, 0.5, 0.75, 1, 1.5,
               0, 0, 0, 0.5, 1),
             byrow = TRUE, ncol = 5)          # weighted matrix for toxicity matrix
                                              # nrow = No.of type; ncol = No. of grade
toxmax <- 2.5

nTTP.all <- nTTP.array(wm, toxmax)

tox.matrix <- prob["MTD4", "flat", , , , ]

nTTP_summary(tox.matrix, nTTP.all, wm)

LuZhangstat/Phase1Mayo documentation built on March 16, 2020, 1:32 a.m.