df_linear_associations: Linear Associations of Blood Biomarkers to BMI, HOMA-IR and...

Description Usage Format Details Source

Description

A data frame containing cross-sectional associations of the Nightingale blood biomarkers to Body Mass Index (BMI), insulin resistance (log(HOMA-IR)) and fasting glucose. For these values a linear regression model was used, adjusted for age and sex.

Usage

1

Format

A data frame (tibble) with 687 rows and 5 columns:

name

Blood biomarker name. Note: glucose is missing as the results are adjusted for this biomarker.

trait

The response variable of the regression model, either BMI, log(HOMA-IR) or fasting glucose.

beta

Linear regression coefficient β.

se

Standard error.

pvalue

P-value.

Details

"Values are beta-correlations from cross-sectional metabolite associations with BMI, log(HOMA-IR) and fasting glucose. For comparison of the patterns of associations, magnitudes are scaled to 1-SD in each of the outcomes (corresponding to 4.2 kg/m2 for BMI, 0.57 for log(HOMA-IR) and 0.56 mmol/l for glucose) per 1-SD log-transformed metabolite concentration. Results were adjusted for sex and age, and meta-analyzed for 11,896 individuals from the four cohorts. Error bars denote 95% confidence intervals; the large sample size and consistency across cohorts make confidence intervals narrow for the cross-sectional linear regression analyses." The values are shown in Figure S5 of A. V. Ahola-Olli et al. (2019): https://www.biorxiv.org/content/early/2019/01/08/513648

Source

These data are taken from the Supplementary material of A. V. Ahola-Olli et al. (2019). https://www.biorxiv.org/content/early/2019/01/08/513648


NightingaleHealth/ggforestplot documentation built on April 10, 2020, 7:01 p.m.