strvalidator-package: Process Control and Internal Validation of Forensic STR Kits
In OskarHansson/strvalidator: Process Control and Validation of Forensic STR Kits
strvalidator-package R Documentation
Process Control and Internal Validation of Forensic STR Kits
Description
STR-validator is a free and open-source R package intended for
process control and internal validation of forensic STR DNA typing kits.
Its graphical user interface simplifies the analysis of data exported from
software like GeneMapper, without requiring extensive knowledge about R. It provides
functions to import, view, edit, and export data. After analysis, the results,
generated plots, heatmaps, and data can be saved in a project for easy access.
Analysis modules for stutter, balance, dropout, mixture, concordance,
typing result, precision, pull-up, and analytical thresholds are available.
In addition, there are functions to analyze GeneMapper bins and panels files.
EPG-like plots can be generated from data. STR-validator can significantly
increase the speed of validation by reducing the time and effort needed to
analyze validation data. It allows exploration of the characteristics of DNA
typing kits according to ENFSI and SWGDAM recommendations. This facilitates
the implementation of probabilistic interpretation of DNA results.
STR-validator was written by and is maintained by Oskar Hansson,
Section of Digitalization and Development, Oslo University Hospital (OUS).
The work initially received external funding from the European
Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no.
285487 (EUROFORGEN-NoE) but development and maintenance are now performed as
part of my position at OUS, and on personal spare time.
Effort has been made to assure correct results. Refer to the main website
for a list of functions specifically tested at build time.
Click Index at the bottom of the page to see a complete list of
functions.
Created and maintained by:
Oskar Hansson, Section for Forensic Biology (OUS, Norway)
More information can be found at:
https://sites.google.com/site/forensicapps/strvalidator
Info and user community at Facebook:
https://www.facebook.com/pages/STR-validator/240891279451450?ref=tn_tnmn
https://www.facebook.com/groups/strvalidator/
The source code is hosted on GitHub:
https://github.com/OskarHansson/strvalidator
Please report bugs to:
https://github.com/OskarHansson/strvalidator/issues
Author(s)
Oskar Hansson oskhan@ous-hf.no
References
Recommended Minimum Criteria for the Validation of Various Aspects of the DNA Profiling Process
http://enfsi.eu/wp-content/uploads/2016/09/minimum_validation_guidelines_in_dna_profiling_-_v2010_0.pdf
Validation Guidelines for Forensic DNA Analysis Methods (2012)
http://media.wix.com/ugd/4344b0_cbc27d16dcb64fd88cb36ab2a2a25e4c.pdf
See Also
Useful links:
OskarHansson/strvalidator documentation built on Aug. 15, 2024, 7:13 a.m.
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| strvalidator-package | R Documentation |
Process Control and Internal Validation of Forensic STR Kits
Description
STR-validator is a free and open-source R package intended for process control and internal validation of forensic STR DNA typing kits. Its graphical user interface simplifies the analysis of data exported from software like GeneMapper, without requiring extensive knowledge about R. It provides functions to import, view, edit, and export data. After analysis, the results, generated plots, heatmaps, and data can be saved in a project for easy access. Analysis modules for stutter, balance, dropout, mixture, concordance, typing result, precision, pull-up, and analytical thresholds are available. In addition, there are functions to analyze GeneMapper bins and panels files. EPG-like plots can be generated from data. STR-validator can significantly increase the speed of validation by reducing the time and effort needed to analyze validation data. It allows exploration of the characteristics of DNA typing kits according to ENFSI and SWGDAM recommendations. This facilitates the implementation of probabilistic interpretation of DNA results.
STR-validator was written by and is maintained by Oskar Hansson,
Section of Digitalization and Development, Oslo University Hospital (OUS).
The work initially received external funding from the European
Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no.
285487 (EUROFORGEN-NoE) but development and maintenance are now performed as
part of my position at OUS, and on personal spare time.
Effort has been made to assure correct results. Refer to the main website
for a list of functions specifically tested at build time.
Click Index at the bottom of the page to see a complete list of
functions.
Created and maintained by:
Oskar Hansson, Section for Forensic Biology (OUS, Norway)
More information can be found at:
https://sites.google.com/site/forensicapps/strvalidator
Info and user community at Facebook:
https://www.facebook.com/pages/STR-validator/240891279451450?ref=tn_tnmn
https://www.facebook.com/groups/strvalidator/
The source code is hosted on GitHub:
https://github.com/OskarHansson/strvalidator
Please report bugs to:
https://github.com/OskarHansson/strvalidator/issues
Author(s)
Oskar Hansson oskhan@ous-hf.no
References
Recommended Minimum Criteria for the Validation of Various Aspects of the DNA Profiling Process http://enfsi.eu/wp-content/uploads/2016/09/minimum_validation_guidelines_in_dna_profiling_-_v2010_0.pdf Validation Guidelines for Forensic DNA Analysis Methods (2012) http://media.wix.com/ugd/4344b0_cbc27d16dcb64fd88cb36ab2a2a25e4c.pdf
See Also
Useful links:
R Package Documentation
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