CohortSizeMax-class: 'CohortSizeMax'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

CohortSizeMax

Description

CohortSizeMax is the class for cohort size that is based on maximum of multiple cohort size rules. The cohort_sizes slot stores a set of cohort size rules, which are again the objects of class CohortSize. The maximum of these individual cohort sizes is taken to give the final cohort size.

Usage

.DefaultCohortSizeMax()

CohortSizeMax(cohort_sizes)

Arguments

cohort_sizes

(list) see slot definition.

Slots

cohort_sizes

(list)
a list of cohort size rules, i.e. objects of class CohortSize.

Note

Typically, end users will not use the .DefaultCohortSizeMax() function.

Examples

# Rule for cohort of size 1 for doses <30 and cohort of size 3 for doses >=30.
my_size1 <- CohortSizeRange(intervals = c(0, 10), cohort_size = c(1, 3))

# Rule for cohort of size 1 until no DLT were observed and cohort of size 3
# as soon as 1 DLT is observed.
my_size2 <- CohortSizeDLT(intervals = c(0, 1), cohort_size = c(1, 3))

# Cohort size rules of class 'CohortSizeMax' which will then be combined with
# the 'max' operation.
mySize <- CohortSizeMax(cohort_sizes = list(my_size1, my_size2))

Roche/crmPack documentation built on April 20, 2024, 1:10 p.m.