DualEndpointEmax-class | R Documentation |
DualEndpointEmax
DualEndpointEmax
is the class for the dual endpoint model with Emax
function for dose-biomarker relationship.
DualEndpointEmax(E0, Emax, ED50, ref_dose_emax = 1, ...)
.DefaultDualEndpointEmax()
E0 |
( |
Emax |
( |
ED50 |
( |
ref_dose_emax |
( |
... |
parameters passed to |
This class extends the DualEndpoint
class so that the dose-biomarker
relationship f(x)
is modelled by a parametric Emax
function:
f(x) = E0 + [(Emax - E0) * (x/x*)]/[ED50 + (x/x*)],
where x*
is a reference dose, E0
and Emax
are the minimum
and maximum levels for the biomarker, and ED50
is the dose achieving
half of the maximum effect 0.5 * Emax
.
All parameters can currently be assigned uniform distributions or be fixed.
E0
(numeric
)
either a fixed number or the two uniform distribution
parameters.
Emax
(numeric
)
either a fixed number or the two uniform
distribution parameters.
ED50
(numeric
)
either a fixed number or the two uniform
distribution parameters.
ref_dose_emax
(positive_number
)
the reference dose x*
(note
that this is different from the ref_dose
in the inherited DualEndpoint
model).
Typically, end users will not use the .DefaultDualEndpointEmax()
function.
DualEndpoint
, DualEndpointRW
, DualEndpointBeta
.
my_model <- DualEndpointEmax(
mean = c(0, 1),
cov = matrix(c(1, 0, 0, 1), nrow = 2),
sigma2W = c(a = 0.1, b = 0.1),
rho = c(a = 1, b = 1),
E0 = c(0, 100),
Emax = c(0, 500),
ED50 = c(10, 200),
ref_dose_emax = 1000
)
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