ShixiangWang/sigminer: Capture Genomic Variation Signatures using Non-Negative Matrix Factorization

Contains functions for identification of copy number signatures (Geoffrey et al. (2018) <doi:10.1038/s41588-018-0179-8>) and mutation signatures (Alexandrov et al. (2018) <doi:10.1038/nature12477>) by non-negative matrix factorization, signature analysis and visualization. It can be used to capture signatures of genomic variation, compare genotype or phenotype features of different signatures and thus uncover the relationship between the mechanism of genomic variation and phenotypes in cancer.

Getting started

Package details

Maintainer
LicenseMIT + file LICENSE
Version0.1.5
URL https://github.com/ShixiangWang/sigminer
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("devtools")
library(devtools)
install_github("ShixiangWang/sigminer")
ShixiangWang/sigminer documentation built on March 19, 2019, 8:44 p.m.