Sun-lab/SAME: Somatic mutation Association test with Measurement Errors

Association analysis using somatic mutations. It accounts for somatic mutation calling uncertainty by modeling the true somatic mutation status as a latent variable and exploiting read count data to augment the mutation calls. Two versions of the test are provided, one for mutation-level analysis using a single somatic mutation (mSAME) and the other one for gene-level analysis using multiple mutations within a gene (gSAME).

install.packages("remotes")
remotes::install_github("Sun-lab/SAME")