PRO-CRM joint decoding marginal modeling
1 | PROCRMjntmar(param.ini = NULL, dose, tox.c, tox.p, skeleton, target)
|
param.ini |
initial value of paramameter, default = rep(0, L) |
dose |
dose level sequence |
tox.c |
toxicity outcome from clinitian |
tox.p |
toxicity outcome from patient |
skeleton |
mapped skeleton for dose levels, a vector of length = # of dose levels (K), should be between 0 and 1 |
target |
targets for (cumulative) toxicity rates, a vector of length = # of toxicity levels (L) |
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