SimCRM: Multi-Trial Wrapper for SimOneCRM()

Description Usage Arguments

Description

Multi-Trial Wrapper for SimOneCRM()

Usage

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SimCRM(n.sim, n, true.tox.rate, skeleton, target,
  working.model = "power", cohort.size = 1,
  allow.dose.skipping = FALSE, allow.escalation.on.toxicity = FALSE,
  seed = NULL)

Arguments

n.sim

# of simulations/trials

n

# of subjects (sample size) in each trial, should be a multiple of cohort.size

true.tox.rate

true (cumulative) toxicity rates, a real matrix where nrow = # of dose levels (K), and ncol = # of toxicity levels (L).

skeleton

mapped skeleton for dose levels, a vector of length = # of dose levels (K), should be between 0 and 1

target

targets for (cumulative) toxicity rates, a vector of length = # of toxicity levels (L)

working.model

working model, character, default = "power" (currently only supports "power")

cohort.size

default = 1

allow.dose.skipping

default = FALSE

allow.escalation.on.toxicity

default = FALSE

seed

seed for RNG


XiaoqiLu/CRMplus documentation built on May 22, 2019, 2:16 p.m.