ER_SET_sig: ER gene signature

In a-thind/PathAnalyser: ER & HER2 Pathway Activity Analysis For Breast Cancer Transcriptomic Datasets

ER gene signature

Description

A list of up-regulated and down-regulated genes constituting the gene signature of ER pathway activation. The ER signature was obtained from the sensitivity to endocrine therapy (SET) genomic index defined using a list of genes co-expressed with the estrogen receptor (ESR1 or ER) from microarray data (437 profiles) originating from newly diagnosed breast cancer independent of outcome and treatment (Symmans et al., 2010).

Usage

ER_SET_sig

Format

A data frame with 160 rows (gene names) and 2 variables:

gene

The HUGO gene symbols of a highly differentially expressed gene when ER pathway is active.

expression

The change in expression of the gene when the pathway is active i.e. -1 for down-regulated genes and 1 for up-regulated genes.

Source

SET index defined by Symmans et al. 2010 (see https://pubmed.ncbi.nlm.nih.gov/20697068/).

References

Symmans, W.F., Hatzis, C., Sotiriou, C., Andre, F., Peintinger, F., Regitnig, P., Daxenbichler, G., Desmedt, C., Domont, J., Marth, C. and Delaloge, S., 2010. Genomic index of sensitivity to endocrine therapy for breast cancer. Journal of clinical oncology, 28(27), p.4111. doi: https://doi.org/10.1200/jco.2010.28.4273

a-thind/PathAnalyser documentation built on May 6, 2022, 9:50 a.m.