HER2_Smid_sig: HER2 gene signature

In a-thind/PathAnalyser: ER & HER2 Pathway Activity Analysis For Breast Cancer Transcriptomic Datasets

HER2 gene signature

Description

A list of up-regulated and down-regulated genes of the ERBB2 (HER2) sub type (which is characterized by high expression of ERBB2) of 344 primary breast tumors from lymph node-negative patients (Smid et al. 2008).

Usage

HER2_Smid_sig

Format

A data frame with 156 rows (gene names) and 2 variables:

gene

The HUGO gene symbols of a highly differentially expressed gene when HER2 pathway is active.

expression

The change in expression of the gene when the pathway is active i.e. -1 for down-regulated genes and 1 for up-regulated genes.

Source

MSigDB (For up-regulated component of the: https://www.gsea-msigdb.org/gsea/msigdb/cards/SMID_BREAST_CANCER_ERBB2_UP.html)

MSigDB (For down-regulated component of the signature: https://www.gsea-msigdb.org/gsea/msigdb/cards/SMID_BREAST_CANCER_ERBB2_DN.html )

References

Smid, M., Wang, Y., Zhang, Y., Sieuwerts, A.M., Yu, J., Klijn, J.G., Foekens, J.A. and Martens, J.W., 2008. Subtypes of breast cancer show preferential site of relapse. Cancer research, 68(9), pp.3108-3114. doi: https://doi.org/10.1158/0008-5472.CAN-07-5644

a-thind/PathAnalyser documentation built on May 6, 2022, 9:50 a.m.