Description Usage Arguments Value Author(s) Examples
This function calls the functions required to run a full ESPRESSO analysis where the model consists of an outcome (binary or continuous) determined by two interacting covariates (a SNP and an environmental exposure)
1 2 | run.espresso.GxE(simulation.params = NULL, pheno.params = NULL,
geno.params = NULL, env.params = NULL, scenarios2run = 1)
|
simulation.params |
general parameters for the scenario(s) to analyse |
pheno.params |
paramaters for the outcome variables |
geno.params |
parameters for the genetic determinant |
env.params |
parameters for the environmental determinant |
scenarios2run |
the indices of the scenarios one wish to analyse |
a summary table that contains both the input parameters and the results of the analysis
Gaye A.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 | {
# load the table that hold the input parameters; each of the table
# hold parameters for 4 scenarios:
# scenario 1: a binary outcome determined by a binary SNP and binary exposure
# and an interaction between the the genetic variant and the environmental exposure
# scenario 2: a binary outcome determined by an additive SNP and continuous
# exposure and an interaction between the the genetic variant and the environmental exposure
# scenario 3: a quantitative outcome determined by a binary SNP and binary exposure,
# and an interaction between the the genetic variant and the environmental exposure
# scenario 4: a quantitative outcome determined by an additive SNP and continuous
# exposure and an interaction between the the genetic variant and the environmental exposure
data(simulation.params)
data(pheno.params)
data(geno.params)
data(env.params)
# run the function for the first two scenarios, two binomial models
run.espresso.GxE(simulation.params, pheno.params, geno.params, env.params, scenarios2run=c(1,2))
# run the function for the last two scenarios, two gaussian models
run.espresso.GxE(simulation.params, pheno.params, geno.params, env.params, scenarios2run=c(3,4))
}
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