ajank/Romulus: Robust Multi-State Identification of Transcription Factor Binding Sites

Romulus is a computational method to accurately identify individual transcription factor binding sites from genome sequence information and cell-type--specific experimental data, such as DNase-seq. It combines the strengths of its predecessors, CENTIPEDE and Wellington, while keeping the number of free parameters in the model robustly low. The method is unique in allowing for multiple binding states for a single transcription factor, differing in their cut profile and overall number of DNase I cuts.

Getting started

Package details

URL http://github.com/ajank/Romulus
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
ajank/Romulus documentation built on June 3, 2017, 2:54 p.m.