mf3: The Fisher Information Matrix (FIM) for one individual

In andrewhooker/PopED: Population (and Individual) Optimal Experimental Design

The Fisher Information Matrix (FIM) for one individual

Description

Compute the FIM for one individual given specific model(s), parameters, design and methods.

Usage

mf3(model_switch, xt, x, a, bpop, d, sigma, docc, poped.db)

Arguments

model_switch	A vector that is the same size as xt, specifying which model each sample belongs to.
xt	A vector of sample times.
x	A vector for the discrete design variables.
a	A vector of covariates.
bpop	The fixed effects parameter values. Supplied as a vector.
d	A between subject variability matrix (OMEGA in NONMEM).
sigma	A residual unexplained variability matrix (SIGMA in NONMEM).
docc	A between occasion variability matrix.
poped.db	A PopED database.

Value

As a list:

ret	The FIM for one individual
poped.db	A PopED database

See Also

Other FIM: LinMatrixH(), LinMatrixLH(), LinMatrixL_occ(), calc_ofv_and_fim(), ed_laplace_ofv(), ed_mftot(), efficiency(), evaluate.e.ofv.fim(), evaluate.fim(), gradf_eps(), mf7(), mftot(), ofv_criterion(), ofv_fim()

andrewhooker/PopED documentation built on Nov. 23, 2023, 1:37 a.m.