An R package developed to estimate population-level frequencies of genetic markers of antimalarial resistance where
Beware: this readme is seven years late. I wrote this code during my PhD. It is the first code I ever made public. It is far from perfect, but better public than private (I hope). Please email me (aimee.taylor@pasteur.fr) if you find any bugs. Package documentation is bare-bones. In addition to this readme, I've added a couple of vignettes, which are based on inst/Test_Run.R and inst/visualise_results.R
The model used to estimate frequencies was first described here: Taylor et al. 2014
The code was first made available in conjunction with this publication: Taylor et al. 2016
A comprehensive description of the model can be found here: methodological chapter of PhD thesis
Various aspects of the code are specific to unpublished chapters of my PhD (full thesis). For example, accounting for inter-child variability when data come from children who experience multiple episodes (chapter 5) and using read-depth information from short-read sequencing data (chapter 6).
Follow the code below to install the model.
install.packages("devtools")
devtools::install_github("aimeertaylor/FreqEstimationModel", build_vignettes = TRUE, dependencies = TRUE)
library(FreqEstimationModel)
help(package = "FreqEstimationModel")
browseVignettes("FreqEstimationModel")
# A quick example of results that can be generated using a simulated data set:
vignette("Quick_example", "FreqEstimationModel")
# Loads an pdf example of the long-form results that can be generated following the quick example:
vignette("Long_results", "FreqEstimationModel")
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