Cladu: Clearance of the unbound fraction of a specific molecule for...
In artemis-toumazi/dfped: Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies
Description
Usage
Arguments
Author(s)
References
See Also
Examples
Description
Compute the clearance of the unbound fraction of a specific molecule for the adult population.
Usage
1
Cladu(Clad, fuAd, Fad)
Arguments
Clad
The apparent clearance for adults.
fuAd
Unbound bioavailability for adults for the molecule.
Fad
Bioavailability for adults.
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com,
Caroline Petit caroline.petit@crc.jussieu.fr,
Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
See Also
Examples
1
2
3
4
Cl_ad <- 3.95
F_ad <- 0.6
fu_ad <- 1
Cladu(Cl_ad, fu_ad, F_ad)
artemis-toumazi/dfped documentation built on May 10, 2019, 1:49 p.m.
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Description Usage Arguments Author(s) References See Also Examples
Description
Compute the clearance of the unbound fraction of a specific molecule for the adult population.
Usage
1 | Cladu(Clad, fuAd, Fad)
|
Arguments
Clad |
The apparent clearance for adults. |
fuAd |
Unbound bioavailability for adults for the molecule. |
Fad |
Bioavailability for adults. |
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
See Also
Examples
1 2 3 4 | Cl_ad <- 3.95
F_ad <- 0.6
fu_ad <- 1
Cladu(Cl_ad, fu_ad, F_ad)
|
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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