fuCh: Unbound fraction of the molecule in the plasma for children.

Description Usage Arguments Author(s) References See Also Examples

Description

Unbound fraction of the molecule in the plasma for children.

Usage

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fuCh(age, fuAd, percAlb, percAlpha1AG)

Arguments

age

The age of children.

fuAd

Unbound fraction of the molecule in adults.

percAlb

Percentage of the molecule binding with albumin.

percAlpha1AG

Percentage of the molecule binding with alpha1-acid glycoprotein.

Author(s)

Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr

References

Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.

Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.

See Also

Clch.Mat

Examples

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## Not run: 
    ########
    # Note: For this example we are using a paediatric database that we have including data of 
    # children from 0 to 19 years old.
    ########

    children <- read.csv("/Users/artemistoumazi/paediatric_data_p3m/children_0_19.csv")
    AGE <- children$Age
    fu_ad <- 1
    perc_alb <- 1
    perc_alpha1AG <- 0 

    fuCh(AGE, fu_ad, perc_alb, perc_alpha1AG)

## End(Not run)

artemis-toumazi/dfped documentation built on May 10, 2019, 1:49 p.m.