concAd: Concentration of a specific molecule in plasma for the adult...
In artemis-toumazi/dfped: Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies
Description
Usage
Arguments
Author(s)
References
See Also
Examples
Description
Compute the concentration of a specific molecule in plasma for the adult population according to the percentage binding with albumin and alpha1-acid glycoprotein.
Usage
1
concAd(percAlb, percAlpha1AG)
Arguments
percAlb
Percentage of the molecule binding with albumin.
percAlpha1AG
Percentage of the molecule binding with alpha1-acid glycoprotein.
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com,
Caroline Petit caroline.petit@crc.jussieu.fr,
Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.
See Also
Examples
1
2
3
perc_alb <- 1
perc_alpha1AG <- 0
concAd(perc_alb, perc_alpha1AG)
artemis-toumazi/dfped documentation built on May 10, 2019, 1:49 p.m.
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Description Usage Arguments Author(s) References See Also Examples
Description
Compute the concentration of a specific molecule in plasma for the adult population according to the percentage binding with albumin and alpha1-acid glycoprotein.
Usage
1 | concAd(percAlb, percAlpha1AG)
|
Arguments
percAlb |
Percentage of the molecule binding with albumin. |
percAlpha1AG |
Percentage of the molecule binding with alpha1-acid glycoprotein. |
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.
See Also
Examples
1 2 3 | perc_alb <- 1
perc_alpha1AG <- 0
concAd(perc_alb, perc_alpha1AG)
|
R Package Documentation
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We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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