artemis-toumazi/dfpk: Bayesian Dose-Finding Designs using Pharmacokinetics (PK) for Phase I Clinical Trials

Statistical methods involving PK measures are provided, in the dose allocation process during a Phase I clinical trials. These methods, proposed by Ursino et al, (2017) <doi:10.1002/bimj.201600084>, enter pharmacokinetics (PK) in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate data from several scenarios and functions to run simulations which their objective is to determine the maximum tolerated dose (MTD).

Getting started

Package details

MaintainerArtemis Toumazi <[email protected]>
LicenseGPL (>= 3) | file LICENSE
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
artemis-toumazi/dfpk documentation built on May 10, 2019, 1:50 p.m.