pk.estim: The pharmacokinetic's (PK) measure of exposure.

In artemis-toumazi/dfpk: Bayesian Dose-Finding Designs using Pharmacokinetics (PK) for Phase I Clinical Trials

The pharmacokinetic's (PK) measure of exposure.

Description

Estimation of the pharmacokinetic's (PK) measure of exposure.

Usage

pk.estim(par, t, dose, conc)

Arguments

par	The pharmacokinetic's parameters.
t	The time sampling.
dose	The doses levels of the drug.
conc	The concentration of the drug in blood plasma.

Author(s)

Artemis Toumazi [e-mail], Moreno Ursino [e-mail], Sarah Zohar [e-mail]

References

Ursino, M., et al, (2017) Dose-finding methods for Phase I clinical trials using pharmacokinetics in small populations, Biometrical Journal, <doi:10.1002/bimj.201600084>.

Toumazi, A., et al, (2018) dfpk: An R-package for Bayesian dose-finding designs using pharmacokinetics (PK) for phase I clinical trials, Computer Methods and Programs in Biomedicine, <doi:10.1016/j.cmpb.2018.01.023>.

See Also

AUC.estim, nsim

Examples

par <- c(2,10,100) 
conc <- c(20,30,40,50,60,70)
t <- seq(0,24,length.out=48)
dose <- c(12.59972,34.65492,44.69007,60.80685,83.68946,100.37111)
pk.estim(par,t,dose,conc)

artemis-toumazi/dfpk documentation built on Sept. 5, 2023, 2:44 a.m.