pk.nca.interval: Compute all PK parameters for a single concentration-time...

In billdenney/pknca: Perform Pharmacokinetic Non-Compartmental Analysis

Compute all PK parameters for a single concentration-time data set

Description

For one subject/time range, compute all available PK parameters. All the internal options should be set by PKNCA.options() prior to running. The only part that changes with a call to this function is the concentration and time.

Usage

pk.nca.interval(
  conc,
  time,
  volume,
  duration.conc,
  dose,
  time.dose,
  duration.dose,
  route,
  conc.group = NULL,
  time.group = NULL,
  volume.group = NULL,
  duration.conc.group = NULL,
  dose.group = NULL,
  time.dose.group = NULL,
  duration.dose.group = NULL,
  route.group = NULL,
  impute_method = NA_character_,
  include_half.life = NULL,
  exclude_half.life = NULL,
  subject,
  sparse,
  interval,
  options = list()
)

Arguments

conc	Measured concentrations
time	Time of the measurement of the concentrations
volume, volume.group	The volume (or mass) of the concentration measurement for the current interval or all data for the group (typically for urine and fecal measurements)
duration.conc, duration.conc.group	The duration of the concentration measurement for the current interval or all data for the group (typically for urine and fecal measurements)
dose, dose.group	Dose amount (may be a scalar or vector) for the current interval or all data for the group
time.dose, time.dose.group	Time of the dose for the current interval or all data for the group (must be the same length as dose or dose.group)
duration.dose, duration.dose.group	The duration of the dose administration for the current interval or all data for the group (typically zero for extravascular and intravascular bolus and nonzero for intravascular infusion)
route, route.group	The route of dosing for the current interval or all data for the group
conc.group	All concentrations measured for the group
time.group	Time of all concentrations measured for the group
impute_method	The method to use for imputation as a character string
include_half.life	An optional boolean vector of the concentration measurements to include in the half-life calculation. If given, no half-life point selection will occur.
exclude_half.life	An optional boolean vector of the concentration measurements to exclude from the half-life calculation.
subject	Subject identifiers (used for sparse calculations)
sparse	Should only sparse calculations be performed (TRUE) or only dense calculations (FALSE)?
interval	One row of an interval definition (see check.interval.specification() for how to define the interval.
options	List of changes to the default PKNCA options (see PKNCA.options())

Value

A data frame with the start and end time along with all PK parameters for the interval

See Also

check.interval.specification()

billdenney/pknca documentation built on April 1, 2024, 10:45 p.m.