pknca_units_table: Create a unit assignment and conversion table

In billdenney/pknca: Perform Pharmacokinetic Non-Compartmental Analysis

Create a unit assignment and conversion table

Description

This data.frame is typically used for the units argument for PKNCAdata(). If a unit is not given, then all of the units derived from that unit will be NA.

Usage

pknca_units_table(
  concu,
  doseu,
  amountu,
  timeu,
  concu_pref = NULL,
  doseu_pref = NULL,
  amountu_pref = NULL,
  timeu_pref = NULL,
  conversions = data.frame()
)

Arguments

concu, doseu, amountu, timeu	Units for concentration, dose, amount, and time in the source data
concu_pref, doseu_pref, amountu_pref, timeu_pref	Preferred units for reporting; conversions will be automatically.
conversions	An optional data.frame with columns of c("PPORRESU", "PPSTRESU", "conversion_factor") for the original calculation units, the standardized units, and a conversion factor to multiply the initial value by to get a standardized value. This argument overrides any preferred unit conversions from concu_pref, doseu_pref, amountu_pref, or timeu_pref.

Value

A unit conversion table with columns for "PPTESTCD" and "PPORRESU" if conversions is not given, and adding "PPSTRESU" and "conversion_factor" if conversions is given.

See Also

The units argument for PKNCAdata()

Examples

pknca_units_table() # only parameters that are unitless
pknca_units_table(
  concu="ng/mL", doseu="mg/kg", amountu="mg", timeu="hr"
)
pknca_units_table(
  concu="ng/mL", doseu="mg/kg", amountu="mg", timeu="hr",
  # Convert clearance and volume units to more understandable units with
  # automatic unit conversion
  conversions=data.frame(
    PPORRESU=c("(mg/kg)/(hr*ng/mL)", "(mg/kg)/(ng/mL)"),
    PPSTRESU=c("mL/hr/kg", "mL/kg")
  )
)
pknca_units_table(
  concu="mg/L", doseu="mg/kg", amountu="mg", timeu="hr",
  # Convert clearance and volume units to molar units (assuming
  conversions=data.frame(
    PPORRESU=c("mg/L", "(mg/kg)/(hr*ng/mL)", "(mg/kg)/(ng/mL)"),
    PPSTRESU=c("mmol/L", "mL/hr/kg", "mL/kg"),
    # Manual conversion of concentration units from ng/mL to mmol/L (assuming
    # a molecular weight of 138.121 g/mol)
    conversion_factor=c(1/138.121, NA, NA)
  )
)

# This will make all time-related parameters use "day" even though the
# original units are "hr"
pknca_units_table(
  concu = "ng/mL", doseu = "mg/kg", timeu = "hr", amountu = "mg",
  timeu_pref = "day"
)

billdenney/pknca documentation built on April 1, 2024, 10:45 p.m.