bmannakee/mapexr: Sensitive and Specific Filtering of Genetic Variants in Xenograft and Primary Tumors
Version 0.1.0

This package is an implementation of the **MAPEX** algorithm described in `Mannakee et al. ...`. The algorithm is a post-variant-calling filter for variants that uses **BLASTN** to determine the fraction of reads supporting a variant call that align best to the site of the variant. It is intended to be used to filter spurious variant calls resulting from mouse DNA contamination in patient-derived xenograft(PDX) tumors, and to evaluate supporting reads for potential paralog risk in primary tumors.

Getting started

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bmannakee/mapexr documentation built on March 21, 2018, 1:26 p.m.