rhoge.bd: Performs bi-directional regression to determine putative...

In bogdanlab/RHOGE: Genome-wide genetic correlation between two complex traits using TWAS effect-size estimates

Description

Performs bi-directional regression to determine putative causal direction between two traits.

Usage

rhoge.bd(trait1, trait2, n1, n2, p1 = NA, p2 = NA, min_regions = 10,
  regions = grch37.eur.loci)

Arguments

trait1	data.frame-like, containing TWAS results for trait 1
trait2	data.frame-like, containing TWAS results for trait 2
n1	integer, sample-size for trait 1 GWAS
n2	integer, sample-size for trait 2 GWAS
p1	double, Transcriptome-wide significance threshold for trait 1 ascertainment. Default is # Bonferroni adjusted 0.05
p2	double, Transcriptome-wide significance threshold for trait 2 ascertainment. Default is # Bonferroni adjusted 0.05
min_regions,	Minimum number of ascertained regions required for bi-directional regression
regions,	data.frame-like containing approximate independent regions. Requires columns (Chr, Start, Stop). Default is estimated blocks in Europeans.

bogdanlab/RHOGE documentation built on May 25, 2019, 3:24 p.m.