README.md

In brentscott93/lasertrapr: Automating the Analysis of Laser Trap Data

lasertrapr

The goal of lasertrapr is to automate the analysis of laser trap data. The app is still being heavily developed, end-users should proceed with caution. For more information and the official documentation refer to the website.

Several peer-reviewed research articles have used either this app or prior versions of the codebase including:

1) FRET and optical trapping reveal mechanisms of actin activation of the power stroke and phosphate release in myosin V 2) A mutation in switch I alters the load-dependent kinetics of myosin Va 3) Myosin's powerstroke occurs prior to the release of phosphate from the active site 4) Positional Isomers of a Non-Nucleoside Substrate Differentially Affect Myosin Function 5) Modeling thick filament activation suggests a molecular basis for force depression

Installation

Current stable version will be hosted on my drat repo.

# install.packages("drat")
drat::addRepo("brentscott93")
install.packages("lasertrapr")

You can install the development version of lasertrapr from GitHub with.

# install.packages("devtools")
devtools::install_github("brentscott93/lasertrapr")

Note: This will install a random snapshot from my last commit.

Disclaimer: This projected was started when I was in grad school at UMass Amherst in the Muscle Biophysics lab. I currently am at WashU in St. Louis in the Greenberg Lab, the developers of the MATLAB based SPASM program for analyzing lasertrap data. Development of lasertrapr is still on-going but at a slower pace than previously. If you want to use lastertrapr and could use a specific update, please open an issue explaining your need (or email me [e-mail]).

brentscott93/lasertrapr documentation built on Jan. 12, 2025, 5:02 a.m.