YATES_BREAST_NATMED_2015: Mutations and copy number from breast cancer patients (PMID:...

In caravagn/evoverse.datasets: Data released in the evoverse

Description

Mutations and copy number from breast cancer patients (PMID: 26099045). n = 50 patients, multi-region whole-exome sequencing. Calls generated from Yates et al. (PMID: 26099045).

Usage

data(YATES_BREAST_NATMED_2015)

Format

Data for the breast cancer cohort by Yates et al. The data has been extracted from the Supplementary tables released in the original Nature Medicine paper (PMID: 26099045). Mutations and copy number are reported as present or absent in each one of the sequenced biopsies. All the data (calls, definition of driver events, etc.) is as released in the original paper. The data is as used in the paper Caravagna et al (PMID: 30171232) to show repeated evolution in breast cancers with REVOLVER.

References

Yates, L.R., Gerstung, M., Knappskog, S., Desmedt, C., Gundem, G., Van Loo, P., Aas, T., Alexandrov, L.B., Larsimont, D., Davies, H. et al., 2015. Subclonal diversification of primary breast cancer revealed by multiregion sequencing. Nature Medicine, 21(7), p.751. PMID: 26099045

Examples

data(YATES_BREAST_NATMED_2015)
YATES_BREAST_NATMED_2015

caravagn/evoverse.datasets documentation built on Feb. 16, 2020, 4:35 a.m.