Description Usage Arguments Value Examples

conditional probabilities of claiming consistency of treatments effects in an MRCT with a survival endpoint by Definition 4.

1 2 | ```
prob.def4(r0, alpha, s, E0, u, f, eps = 0.1, n = 1e+05, lamda,
lamda_cen, L)
``` |

`r0` |
True overall log hazard ratio |

`alpha` |
The risk of rejecting the null hypothesis H0:r0>=0 when it is really true |

`s` |
Number of regions participating in the MRCT |

`E0` |
Event number of all regions with two groups combined |

`u` |
A vector presents ratios of true regional log hazard ratios to true overall log hazard ratio r=u*r0 |

`f` |
A Vector presents proportions of total event number assigned to each region |

`eps` |
Significance level of not rejecting H0 in Definition 4 |

`n` |
Simulation times |

`lamda` |
The event hazard rate for placebo |

`lamda_cen` |
The discontinuation hazard rate |

`L` |
The whole study duration of fixed study duration design |

A list

1 2 3 4 5 6 |

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