perturbatr does stage-wise analysis of large-scale genetic perturbation screens for integrated data sets consisting of multiple screens. For multiple integrated perturbation screens a hierarchical model that considers the variance between different biological conditions is fitted. The resulting list of gene effects is then further extended using a network propagation algorithm to correct for false negatives.
|Bioconductor views||CellBasedAssays ImmunoOncology Network Regression|
|Maintainer||Simon Dirmeier <[email protected]>|
|Package repository||View on GitHub|
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