Author: Ying Shen, Andrea H. Bild, David Jenkins, and W. Evan Johnson
ASSIGN is a computational tool to evaluate the pathway deregulation/activation status in individual patient samples. ASSIGN employs a flexible Bayesian factor analysis approach that adapts predetermined pathway signatures derived either from knowledge-based literature or from perturbation experiments to the cell-/tissue-specific pathway signatures. The deregulation/activation level of each context-specific pathway is quantified to a score, which represents the extent to which a patient sample encompasses the pathway deregulation/activation signature.
ASSIGN is available on Bioconductor:
if (!requireNamespace("BiocManager", quietly=TRUE)) install.packages("BiocManager") BiocManager::install("ASSIGN")
Or install the development version from github:
# install.packages("devtools") devtools::install_github("compbiomed/ASSIGN")
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