GenerateNetwork: Generate a gene-network to perform a KEGG pathway analysis on...

Description Usage Arguments Value

View source: R/GenerateNetwork.R

Description

This function creates an interactive dashboard with two tabs. The first tab "Not-Isolated Genes" shows a three-colour networks of the not-isolated genes, i.e. the genes sharing at least one KEGG pathway. The second tab "Full Network" shows a three-colour networks of all the genes selected by the method (all the not zero signatures). Different node colors are used to show a probability measure between the genes and the disease under investigation as follows: Blue color is used for the bottom 501 tissue-specific genes (mapped down genes), White color is used for genes that are not listed as tissue-specific in the HumanBase database (not mapped genes).

Usage

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GenerateNetwork(
  ListOfGenes = NULL,
  header = TRUE,
  diseaseID = NULL,
  nodesCols = c("#EFCFD4", "#D9E3FC", "#FFFFFF")
)

Arguments

ListOfGenes

a two-column data frame composed by gene names and beta coefficients

diseaseID

the disease ID identified by Disease Ontology (DO) (https://disease-ontology.org)

ListHeader

true if the genes' list has a header, false otherwise

nodesCol

the colours of the nodes. Default values are orange, greeen and purple for mapped-up, mapped down and not mapped genes, respectively.

Value

Create KEGG network and open the dashboard on the browser.


cosmonet-package/COSMONET documentation built on Dec. 24, 2021, 9:12 p.m.