de.bioRxiv.240846: Simulated '3+3/PC' dose-titration study from bioRxiv paper...

In dcnorris/DTAT: Dose Titration Algorithm Tuning: a framework for dose individualization

Description

This is a length-10 list

Format

The format is: List of 10 $ :'data.frame': 3 obs. of 4 variables: ..$ id : int [1:3] 1 2 3 ..$ period: num [1:3] 1 1 1 ..$ dose : num [1:3] 1 1 1 ..$ dlt : logi [1:3] FALSE FALSE FALSE $ :'data.frame': 9 obs. of 4 variables: ..$ id : int [1:9] 1 2 3 4 5 6 1 2 3 ..$ period: num [1:9] 1 1 1 2 2 2 2 2 2 ..$ dose : num [1:9] 1 1 1 1 1 1 2 2 2 ..$ dlt : logi [1:9] FALSE FALSE FALSE FALSE FALSE FALSE ... $ :'data.frame': 18 obs. of 4 variables: ..$ id : int [1:18] 1 2 3 4 5 6 1 2 3 7 ... ..$ period: num [1:18] 1 1 1 2 2 2 2 2 2 3 ... ..$ dose : num [1:18] 1 1 1 1 1 1 2 2 2 1 ... ..$ dlt : logi [1:18] FALSE FALSE FALSE FALSE FALSE FALSE ... $ :'data.frame': 30 obs. of 4 variables: ..$ id : int [1:30] 1 2 3 4 5 6 1 2 3 7 ... ..$ period: num [1:30] 1 1 1 2 2 2 2 2 2 3 ... ..$ dose : num [1:30] 1 1 1 1 1 1 2 2 2 1 ... ..$ dlt : logi [1:30] FALSE FALSE FALSE FALSE FALSE FALSE ... $ :'data.frame': 45 obs. of 4 variables: ..$ id : int [1:45] 1 2 3 4 5 6 1 2 3 7 ... ..$ period: num [1:45] 1 1 1 2 2 2 2 2 2 3 ... ..$ dose : num [1:45] 1 1 1 1 1 1 2 2 2 1 ... ..$ dlt : logi [1:45] FALSE FALSE FALSE FALSE FALSE FALSE ... $ :'data.frame': 61 obs. of 4 variables: ..$ id : int [1:61] 1 2 3 4 5 6 1 2 3 7 ... ..$ period: num [1:61] 1 1 1 2 2 2 2 2 2 3 ... ..$ dose : num [1:61] 1 1 1 1 1 1 2 2 2 1 ... ..$ dlt : logi [1:61] FALSE FALSE FALSE FALSE FALSE FALSE ... $ :'data.frame': 77 obs. of 4 variables: ..$ id : int [1:77] 1 2 3 4 5 6 1 2 3 7 ... ..$ period: num [1:77] 1 1 1 2 2 2 2 2 2 3 ... ..$ dose : num [1:77] 1 1 1 1 1 1 2 2 2 1 ... ..$ dlt : logi [1:77] FALSE FALSE FALSE FALSE FALSE FALSE ... $ :'data.frame': 89 obs. of 4 variables: ..$ id : int [1:89] 1 2 3 4 5 6 1 2 3 7 ... ..$ period: num [1:89] 1 1 1 2 2 2 2 2 2 3 ... ..$ dose : num [1:89] 1 1 1 1 1 1 2 2 2 1 ... ..$ dlt : logi [1:89] FALSE FALSE FALSE FALSE FALSE FALSE ... ..- attr(, "stop.esc")= num 7 $ :'data.frame': 99 obs. of 4 variables: ..$ id : int [1:99] 1 2 3 4 5 6 1 2 3 7 ... ..$ period: num [1:99] 1 1 1 2 2 2 2 2 2 3 ... ..$ dose : num [1:99] 1 1 1 1 1 1 2 2 2 1 ... ..$ dlt : logi [1:99] FALSE FALSE FALSE FALSE FALSE FALSE ... ..- attr(, "stop.esc")= num 7 $ :'data.frame': 104 obs. of 4 variables: ..$ id : int [1:104] 1 2 3 4 5 6 1 2 3 7 ... ..$ period: num [1:104] 1 1 1 2 2 2 2 2 2 3 ... ..$ dose : num [1:104] 1 1 1 1 1 1 2 2 2 1 ... ..$ dlt : logi [1:104] FALSE FALSE FALSE FALSE FALSE FALSE ... ..- attr(*, "stop.esc")= num 7

References

Norris DC. Precautionary Coherence Unravels Dose Escalation Designs. bioRxiv. December 2017:240846. doi:10.1101/240846. https://www.biorxiv.org/content/early/2017/12/29/240846

Examples

data(de.bioRxiv.240846)
## maybe OXDSplot(last(de))

dcnorris/DTAT documentation built on May 7, 2019, 10:45 p.m.