Description Usage Arguments Value Author(s) References See Also
This function is invoked recursively by de.sim
, to simulate a
complete 3+3/PC study. For details on the 3+3/PC rules, please see the
references below.
1 |
de |
A data frame describing the events of a dose-titration study underway |
MTDi |
Vector of MTDi's, indexed by participant id |
verbose |
Logical: the default provides verbose output (for debugging and instruction) when invoked interactively from the R prompt, but not when invoked 'programmatically' by client code. |
n.doses |
When specified, prevents escalation to (n+1)th dose |
A data frames summarizing the events of a dose-titration study up to a given DLT assessment period, having columns as follows:
id Integer: participants are numbered in order of enrollment, starting from 1
period Integer: DLT assessment periods of the study, numbered from 1
dose Integer: dose level received by id
during
period
dlt Logical: did participant id
experience a DLT
during period
?
David C. Norris
Norris DC. Precautionary Coherence Unravels Dose Escalation Designs. bioRxiv. December 2017:240846. doi:10.1101/240846. https://www.biorxiv.org/content/early/2017/12/29/240846
de.sim
invokes step
to simulate a full study.
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