step: Recursively simulate a '3+3/PC' dose-titration study

Description Usage Arguments Value Author(s) References See Also

Description

This function is invoked recursively by de.sim, to simulate a complete 3+3/PC study. For details on the 3+3/PC rules, please see the references below.

Usage

1
step(de, MTDi, verbose = is.null(sys.call(-1)), n.doses = Inf)

Arguments

de

A data frame describing the events of a dose-titration study underway

MTDi

Vector of MTDi's, indexed by participant id

verbose

Logical: the default provides verbose output (for debugging and instruction) when invoked interactively from the R prompt, but not when invoked 'programmatically' by client code.

n.doses

When specified, prevents escalation to (n+1)th dose

Value

A data frames summarizing the events of a dose-titration study up to a given DLT assessment period, having columns as follows:

Author(s)

David C. Norris

References

Norris DC. Precautionary Coherence Unravels Dose Escalation Designs. bioRxiv. December 2017:240846. doi:10.1101/240846. https://www.biorxiv.org/content/early/2017/12/29/240846

See Also

de.sim invokes step to simulate a full study.


dcnorris/DTAT documentation built on May 7, 2019, 10:45 p.m.