deruncie/GridLMM: Efficient Mixed Models for GWAS with multiple Random Effects

Fits approximate Linear Mixed Models with multiple random effects. The fitting process is optimized for repeated evaluation of the random effect model with different sets of fixed effects, ex. for GWAS analyses. The approximation is due to the use of a discrete grid of possible values for the random effect variance component proportions. We include functions for both frequentist and Bayesian GWAS, (Restricted) Maximum Likelihood evaluation, Bayesian Posterior inference of variance components, and Lasso/Elastic Net fitting of high-dimensional models with random effects.

Getting started

Package details

AuthorDaniel E Runcie
MaintainerDaniel Runcie <[email protected]>
LicenseMIT + file LICENSE
Version0.0.0.9000
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("devtools")
library(devtools)
install_github("deruncie/GridLMM")
deruncie/GridLMM documentation built on Aug. 26, 2018, 9:31 p.m.