combine_doses: Choose dose combinations to be investigated, and plot the...

In dominicmagirr/dosecombo: Combination Dose Escalation

Description

Choose dose combinations to be investigated, and plot the prior probabilities of toxicity.

Usage

combine_doses(mono_model_1, mono_model_2, eta_mean, eta_prec, doses_1, doses_2,
  over_limit)

Arguments

mono_model_1	An object of class "LogisticLogNormal".
mono_model_2	An object of class "LogisticLogNormal".
eta_mean	Prior mean for interaction parameter.
eta_prec	Prior precision for interaction parameter.
doses_1	The doses of drug 1 to be tested.
doses_2	The doses of drug 2 to be tested.
over_limit	A number between 0 and 1. If the probability of overdosing is more than 'over_limit' then this dose will be declared inadmissible.

Value

A list of 8 items: - dose combinations on original scale, - dose combinations on log scale, - reference dose 1, - reference dose 2, - over_limit (maximum acceptable probability of overdosing) - plot of prior distribution, - plot of prior distribution including marginals.

dominicmagirr/dosecombo documentation built on May 6, 2019, 4:32 p.m.