#' PKPDdatasets
#'
#' @name PKPDdatasets
#' @docType package
NULL
#' One-compartment pharmacokinetic data given single oral dose
#'
#' A dataset containing dose, plasma concentration and time data, as well as
#' demographic data of Age, Weight, Gender, and Race for each individual
#'
#' \itemize{
#' \item ID. Numerical ID (1--50)
#' \item Time. Time in hours (0--24)
#' \item Amt. Amount of drug given, time dependent, in milligrams
#' \item Conc. Plasma concentration in mg/L
#' \item Age. Age in years
#' \item Weight. Weight in kg
#' \item Gender. Male or Female gender identification
#' \item Race. Ethnicity
#' \item Dose. Dose given to each individual in milligrams
#' }
#'
#' @docType data
#' @keywords datasets
#' @name sd_oral_richpk
#' @usage data(sd_oral_richpk)
#' @format A data frame with 4300 rows and 9 variables
NULL
#' One-compartment single IV bolus PKPD
#'
#' A dataset containing simulated PKPD data. A single IV bolus dose was given and rich pharmacokinetic
#' and pharmacodynamic measurements were taken. Demographic data of Age, Weight, Gender, and Race were collected.
#'
#' The model used is a one-compartment PK model with allometric model of weight on CL (exp 0.75) and volume (exp 1)
#' with direct PD effect (Emax model).
#'
#' \itemize{
#' \item ID. Numerical ID (1-100)
#' \item TIME Time in hours (0-12)
#' \item COBS. Plasma concentration in
#' \item EOBS.
#' \item WEIGHT. Weight in kg
#' \item AGE. Age in years
#' \item DOSE. Three dose levels: 1, 10, and 100 mg
#' \item SEX. Male or Female gender identification
#' \item RACE. AfricanAmerican, Caucasian, Others, and Asian races
#' \item AMT. Amount of drug given, time dependent, in milligrams
#' }
#' @details
#' Parameters used to simulate data:
#' \tabular{lcr}{
#' Parameter \tab Mean \tab Variance (BSV)\cr
#' CL (L/hr) \tab 1 \tab 0.16 (40\%)\cr
#' V (L) \tab 10 \tab 0.09 (30\%)\cr
#' Residual error: Proportional \tab 0 \tab 10\%\cr
#' Emax \tab 10 \tab sd = 1.4 units\cr
#' EC50 (mg/L) \tab 2 \tab 0.09 (30\%)\cr
#' Residual Error on Effect \tab 0 \tab sd = 0.5 units
#' }
#' @docType data
#' @keywords datasets
#' @name sd_iv_rich_pkpd
#' @usage data(sd_iv_rich_pkpd)
#' @format A data frame with 480 rows and 10 variables
NULL
#' IV and oral pharmacokinetic data for daptomycin
#'
#' A dataset containing simulated dapagliflozin PK. A single IV dose followed by 3 escalating oral doses
#' \itemize{
#' \item ID. Numerical ID (1-24)
#' \item TIME. Nominal Time after first dose (hrs)
#' \item TAD. Time After Dose (hrs)
#' \item COBS. Observed Concentration (ug/L)
#' \item AMT_IV. IV dose amount when given (ug)
#' \item AMT_ORAL. Oral dose amount when given (ug)
#' \item OCC. Occasion, associated with each dosing event
#' \item AGE. Age (years)
#' \item WEIGHT Weight (kg)
#' \item GENDER. Gender flag (female=1, male=0)
#' \item FORMULATION Formulation associated with dose (IV or oral)
#' }
#' @docType data
#' @keywords datasets
#' @name dapa_IV_oral
#' @usage data(dapa_IV_oral)
#' @format A data frame with 1536 rows and 11 variables
NULL
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.