R/categorical_datasets.R

In dpastoor/PKPDdatasets: data sets for pharmacometric analysis and visualization

#' Simulated anti-inflammatory pain trial
#' 
#' CTM_Nopain is a novel anti-inflammatory agent under preliminary investigation.  
#' A dose-ranging trial was conducted comparing placebo with 3 doses of CTM_Nopain (5mg, 20mg and 80 mg QD).  
#' The maximum tolerated dose is 160 mg per day.  
#' Plasma concentrations (mg/L) of the drug were measured at 0, 0.5, 1, 1.5, 2, 2.5, 3-8 hours. 
#' Pain score (0=no pain, 1=mild, 2=moderate, 3=severe) were obtained at time points when plasma concentration was collected.  
#' A pain score of 2 or more is considered as no pain relief. 
#' The model used is a one-compartment PK model with allometric model of weight on CL (exp 0.75) and volume (exp 1) 
#' with direct PD effect (Emax model). 
#' 
#' \itemize{
#'   \item ARM Factor with 4 levels
#'   \item ID. Numerical ID  (1-160)
#'   \item TIME Time in hours 
#'   \item CONC Concentration (mg/L)
#'   \item PAINRELIEF 0 (no relief) or 1 (relief)
#'   \item PAINSCORE categorical pain score
#'   \item DOSE Dose Given
#' }
#' @docType data
#' @keywords datasets
#' @name pain_relief
#' @usage data(pain_relief)
#' @format A data frame with 1920 rows and 7 variables
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