Vulcan (VirtUaL ChIP-Seq Analysis through Networks) is a package that interrogates gene regulatory networks to infer cofactors significantly enriched in a differential binding signature coming from ChIP-Seq data. In order to do so, our package combines strategies from different BioConductor packages: DESeq for data normalization, ChIPpeakAnno and DiffBind for annotation and definition of ChIP-Seq genomic peaks, csaw to define optimal peak width and viper for applying a regulatory network over a differential binding signature.
|Author||Federico M. Giorgi, Andrew N. Holding, Florian Markowetz|
|Bioconductor views||ChIPSeq GeneExpression NetworkEnrichment SystemsBiology|
|Maintainer||Federico M. Giorgi <[email protected]>|
|Package repository||View on GitHub|
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